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This study was performed to investigate the effect of aluminum compound on the aluminum contents and histological change in brain tissue of rats. Seventy five male Sprague-Dawley strains were divided into five groups consisting of the control, 250 ppm AlCl₃group, 500 ppm AlCl₃group, 250 ppm Al₂(SO₄)₃group, 500 ppm Al₂(SO₄)₃group and kept on the diet for 2 weeks. The weight gain was increased by administration of AlCl₃but decreased by administration of Al₂(SO₄)₃as compared to control group. The aluminum contents in brain tissue of each group; 250 ppm AlCl₃group, 500 ppm AlCl₃group, 250 ppm Al₂(SO₄)₃group and 500 ppm Al₂(SO₄)₃group were 64.63, 102.21, 132.64 and 180.41 ppm, respectively. Aluminum accumulation in brain tissue was higher with administration of Al₂(SO₄)₃than with administration of AlCl₃. In AlCl₃administration group, multiple small intracytoplasmic granules and microvacuole were seen in large pyramidal cells of cortex and granulovacuolar degeneration. In Al₂(SO₄)₃administration group revealed pollagis pallor, cellular pyknosis, microcavitation resulted from edema in deeper cortical layers were observed. Blue-pigmentation which represents the accumulation of aluminum was noted in granulovacuolar degeneration site in Al₂(SO₄)₃administration group.
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